Immunity publication and commentary

Joseph, Sam, Bana Jabri, and coauthors publish in Immunity on how GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology.

Immunity also published an accompanying commentary that highlights our conceptual contributions:

The study fills a conceptual gap, providing strong new evidence that GATA4 is a critical player in gut regionalization by orchestrating metabolism, immunity, and microbiota colonization to maintain tissue homeostasis. It also underscores the potential relevance of GATA4 in the pathogenesis of intestinal inflammatory diseases.